| Product Name: | Tamoxifen Citrate |
| Alias: | TAM;Nolvadex |
| CAS No.: | 10540-29-1 |
| Molecular Formula: | C26H29NO  |
| Molecular Weight: | 371.51 |
| Purity: | ≥99% |
| Appearance: | White power . |
| Use: | Antitumor drugs raw material, suitable for breast cancer. |
| Packing: | According to customer requirements for packaging |
Tamoxifen Citrate quick details
Tamoxifen Citrate Uses
Tamoxifen is used to treat breast cancer that has spread to other parts of the body (metastatic breast cancer), to treat breast cancer in certain patients after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer. It works by interfering with the effects of estrogen in the breast tissue.How to use Tamoxifen Citrate
Read the Medication Guide provided by your pharmacist before you start using tamoxifen and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth with or without food, usually once or twice daily for 5 years, or as directed by your doctor. Daily dosages greater than 20 milligrams are usually divided in half and taken twice a day, in the morning and evening, or as directed by your doctor. If you are using the liquid, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to therapy. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. If you have breast cancer that has spread to other parts of the body, you may experience increased bone/cancer pain and/or disease flare-up as you start taking tamoxifen. In some cases, this may be a sign of a good response to the medication. Symptoms include increased bone pain, increased tumor size, or even new tumors. These symptoms usually disappear quickly. In any case, report these symptoms right away to your doctor. Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. (See also Precautions section.) Tamoxifen Citrate Class: Antiestrogen Trade Names Tamoxifen Citrate - Tablets, oral 10 mg - Tablets, oral 20 mg Pharmacokinetics Absorption Tamoxifen C max is 40 ng/mL (range, 35 to 45 ng/mL), T max is approximately 5 h after dosing, and steady state is achieved in approximately 4 wk. N-desmethyl tamoxifen C max is 15 ng/mL (range, 10 to 20 ng/mL). Steady state is achieved in approximately 8 wk. Metabolism Tamoxifen is extensively metabolized. The major metabolite is N-desmethyl tamoxifen with biological activity similar to tamoxifen. It is a substrate of CYP-450 3A, 2C9, 2D6, and an inhibitor of P-glycoprotein. Elimination Tamoxifen half-life is 5 to 7 days; 65% of a dose is excreted over a 2-wk period, with fecal excretion as the primary route of elimination. N-desmethyl tamoxifen half-life is approximately 14 days. Special Populations Hepatic Function Impairment The effects of reduced liver function have not been determined. Elderly The effects of age on the pharmacokinetics of tamoxifen have not been determined. Children In pediatric patients, an average steady-state C max and AUC were 187 ng/mL and 4,110 ng•h/mL, respectively, and steady-state C max occurred approximately 8 h after dosing. Cl/F as body weight adjusted in female pediatric patients was approximately 2.3-fold higher than in female breast cancer patients. In the youngest cohort of female pediatric patients (2 to 6 y of age), Cl/F was 2.6-fold higher; in the oldest cohort (7 to 10.9 y of age), Cl/F was approximately 1.9-fold higher. Gender The effects of gender on the pharmacokinetics of tamoxifen have not been determined. Race The effects of race on the pharmacokinetics of tamoxifen have not been determined. Indications and Usage For the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation; for the treatment of axillary node-negative breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation; in women with ductal carcinoma in situ (DCIS) following breast surgery and radiation to reduce the risk of invasive breast cancer; treatment of metastatic breast cancer in women and men; to reduce the incidence of breast cancer in women at high risk of breast cancer. Unlabeled Uses Ovulation stimulation in specially selected anovulatory women desiring pregnancy; management and treatment of some types of mastalgia (eg, cyclical); malignant carcinoid tumor and carcinoid syndrome; migraine associated with menstruation; oligozoospermia; McCune-Albright syndrome in female pediatric patients (in combination with other agents); metastatic melanoma; desmoid tumors; gynecomastia. Contraindications Hypersensitivity to drug; women who require concomitant coumarin-type anticoagulant therapy or women with a history of deep vein thrombosis (DVT) or pulmonary embolus (PE) (reduction of breast cancer incidence in high-risk women/DCIS only).Tamoxifen Citrate Dosage and Administration
Breast Cancer Adults PO 20 to 40 mg daily for 5 y. Ductal Carcinoma In Situ, Reduction in Breast Cancer Incidence in High-Risk Women Adults PO 20 mg daily for 5 y. General Advice Divide dosages greater than 20 mg/day (morning and evening). Storage/Stability Store between 68° and 77°F. Protect from light. Drug Interactions Aminoglutethimide Tamoxifen concentrations may be reduced. Coadministration is not recommended. Anastrozole Plasma concentrations of anastrozole may be decreased. Do not coadminister. Bromocriptine Tamoxifen concentrations may be increased. An addition, bromocriptine GI adverse reactions (eg, abdominal pain) may be increased. Avoid coadministration if serious bromocriptine adverse reactions occur. Cation exchange resins (eg, sodium polystyrene sulfonate) Coadministration of cation exchange resins and tamoxifen may cause serious GI adverse events such as colonic necrosis. Coadministration is not recommended.Antiestrogen、Sex Enhancement Series pictures
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1.For products exported we can offer COA Certificate and official PI. 2.We are manufacturer with own lab and factory, can provide high quality products with factory price. 3.Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7x24h for you to contact. 4.Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express. 5.Customs pass and satisfied rate ≥99%. 6.For hot sale products we have stock in there for transferring. 7.Products purity is test by our quality department strictly before sending, and you can askthe third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after our confirmation will we send it out to you. 8.We have different couriers to different countries. 9.We have clients throughout the world.Order Process
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Q1: Have your Product Quality been Approved by the Third Party Lab? A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. Q2: How do you treat quality complaint? A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss. Q3: Do you Accept Sample Order? A: Yes, we can accept small order from 10g, 100g and 1kg for your evaluation quality of our goods. Q4: Is there any discount? A: Yes, for the larger quantity, we always support with better price for our further cooperation. Q5: Do you accept VISA business credit card? A: Sorry we don't accept VISA credit card, but we'd like to accept the bank transfer, Western Union, Paypal or Bitcoin. Q6: How long does it take the goods to arrive? It is Depending on your location, For the small order, please expect the 5-7 days by DHL,UPS,TNT, FEDEX, EMS and so on. For the mass order, please allow the 5-8 days by Air or 20-35 days by Sea. Q7: Do you have any reshipment policy? Of course, we have the good after-sale service and re-shipment policy if the parcel lose. Our long association with our clients has brought great benefits, we always take the upmost care in the packaging of our products. Our clients will confirm this as even they struggle to find them without help at times. But in spite of our best efforts, it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish a long term relationship with each other. Q8: Can I get a sample? A: Of course. For most products, we can provide you a free sample to test the quality, while the shipping cost should be undertook by your side. We have formed a technology and management team that cooperate closely with some overseas Labs all speak highly of our safe shipping and goods. please do not hesitate to contact us.Our Related Products
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Hjtc (Xiamen) Industry Co., Ltd.
Xiamen Huayongjian Biotechnology Co., Ltd.
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