Abstract
Sermorelin, also known as GRF 1-29, is a synthetic peptide belonging to Hormone Releasing Hormone. Sermorelin Acetate is a truncated analog of a hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human hormone. Sermorelin works by promoting the secretion of Human Hormone from the pituitary gland. It stimulates the pituitary gland to naturally produce increased amounts of human hormone. The increased volume of human hormone produced by the pituitary gland causes an increase in the production of Insulin-Like Factor-1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient. Sermorelin is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human grow steroid releasing hormone, and is thought to be the shortest fully functional fragment of GHRH.Sermorelin is used as a test for grow steroid secretion. It is also used as doping substance in sports. Used extensively in Anti-aging Therapy often in conjunction with Test in men. Safer alternative to Human Grow steroid.How Does It Work
Gonadorelin is a hormone that is produced naturally by the hypothalamus in the brain. It is also known as gonadotrophin-releasing hormone or GnRH.Gonadorelin stimulates the pituitary gland in the brain to release the sex hormones luteinising hormone (LH) and follicle stimulating hormone (FSH). In women, FSH stimulates the production of oestrogen and the development of eggs in the ovaries. LH stimulates the ovaries to release an egg (ovulation). In men, LH stimulates the testicles to produce the hormone testosterone and FSH stimulates the testicles to produce sperm. Gonadorelin is given by injection to check whether the pituitary gland is producing LH and FSH in the correct levels. This can help in the diagnosis of various hormonal disorders, including infertility, delayed puberty and hypogonadism.Application
1) Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH 2) Gonadorelin is becoming a gonadotrophin releasing hormone for athletes (especially strength athletes and bodybuilders) it can significantly help them as following: - To build massive muscle mass - Incresing strength, endurance and performance - Achieving a better and faster recovery Sermorelin promotes healthy function of the pituitary by binding to specific receptor to increase production and secretion of endogenous HGH. Pituitary is an endocrine gland located on the hypothalamus at the base of the brain. It secretes hormones that control growth, blood pressure, function of sex organs, thyroid glands, metabolism, pregnancy, childbirth, temperature and pain relief among others. Sermorelin helps in the improvement of a wide variety of the body functions such as muscle mass, the bone mineral density and hence, muscle strength, exercise performance, the metabolic function, energy, libido and sexual performance, and even the improvement of quality life in general. An additional benefit in the use of Sermorelin is the stimulation of fat reduction. This peptide can regulate the immune function, which is the protection process of an organism against diseases. This function detects any type of threats to start its self-defense and eliminate them. Sermorelin can help in the prevention of joint deterioration and heart disease. People with arthritis can be benefited of positive results that this peptide brings in the regeneration of joint. Hearth disease is related to growth hormone deficiency but if this hormone is reestablished to its optimal levels, heart health can be improved.More Details
1.Missing An InjectionIf an injection is delayed by 2-3 days, this should not make a big difference. But you should try to have your injections as regularly as possible. 2.Other Medicines
Triptorelin can interact with other drugs. This includes medicines you can buy in a shop or chemist. Tell your doctor about any medicines you are taking, including ones you can buy for yourself, complementary therapies, vitamins and herbal drugs. 3.Medical Treatment
If you need to go into hospital for any reason other than cancer, always tell the doctors and nurses that you are taking triptorelin. Explain you are taking hormonal therapy that no one should stop or restart without advice from your cancer doctor.
Description
Sermorelin (INN) (trade name is Geref), also known as GHRH (1-29), is a growth hormone-releasing hormone (GHRH) analogue used as a diagnostic agent. It is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human GHRH, and is thought to be the shortest fully functional fragment of GHRH. It is used as a diagnostic agent to assess growth hormone (GH) secretion. Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth -releasing hormone (GHRH or GRF) consisting of 44 amino acid residues. It stimulates the pituitary gland to naturally produce increased amounts of human growth . Sermorelin Acetate is a truncated analog of a growth releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human growth . The increased volume of human growth () produced by the pituitary gland causes an increase in the production of Insulin-Like Growth -1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient.Usage
Sermorelin, along with the other peptides you will use, comes as a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water (BC water) or sodium chloride meant for injection. Injections can be administered one hour before workout at a dose of 200mcg-300mcg. Normally, Sermorelin injections are taken before bed at around 300mcgs. Of course, as with any GHRH, you will want to use this peptide alongside a GHRP like GHRP-2 or Ipamorelin for maximum release of growth hormone stores. Ideally, though user could still benefit from using a GHRH like CJC 1295 with DAC and a GHRP like Ipamorelin throughout the day and then utilize Sermorelin as a pre-bed timed dose. Do not discount Sermorelin as simply an anti-aging peptide. It can still help promote the growth of lean body mass and increase the availability of IGF-1 in the blood stream.COA
| Test Items | Specification | Test Results |
| Description | White or almost white crystalline powder | White crystalline powder |
| Melting Point | 191.0~193.0ºC | 192ºC |
| Loss of drying | ≤1.0% | 0.5% |
| Heavy Metal | ≤20ppm | 15ppm |
| TLC | Only one spot | Only one spot |
| Assay | ≥99.5% | 99.91% |
| Conclusion | It complies with the USP 32. | |
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How To Use Sermorelin Acetate
Use sermorelin acetate as directed by your doctor. Check the label on the medicine for exact dosing instructions.- Sermorelin acetate is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using sermorelin acetate at home, carefully follow the injection procedures taught to you by your health care provider.
- If sermorelin acetate contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- Do not shake sermorelin acetate when mixing.
- Use sermorelin acetate immediately after mixing. Discard any unused medicine.
- All other hormone therapy should be stopped 1 week before using sermorelin acetate. Contact your doctor or pharmacist if you have questions.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of sermorelin acetate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.